Thankfully I resolved my issue. I did have the channels linked but was only getting signal down the left channel thus only hearing sound in my left ear. Come to find out that the stereo channels would only work when I mapped the stereo channels in the I/O menu on odd-even numbers. For example stereo channels 13 & 14 mapped on outputs 8 & 9 would not work, but if they are mapped to 9 & 10 they will work. I think having that listed in the me500 manual would help out a lot of people and save a whole lot of time.
Thank you for your response!
We’ve been using a PC on Windows 10 and connecting it via USB to the USB port on the back of the board.
I’ve now switched it to a MacBook pro running OS Big Sur 11.01 which I had just recently wiped and we are now experiencing the same issue but less frequently.