There have been early reports of problems with audio files in Windows 10, but Microsoft is aware of the problems and is reportedly working on patches right now. The problems manifest differently with different devices, so it may take some time to work out the bugs in the “upgrade”… but what’s new about that scenario in the brave new world of digital?
Actually, I am having one problem but I am not sure it is related to Windows 10. I cannot copy tracks from a Pro Tools session (following the files structure guidelines), to a USB drive and have them play back on the QU-16.