Don’t!
Send mix78 to the presonus and avoid all the needless effort and potential problems.
We looked at usb and the presonus and went with the audio i/f as being better.
See messages here some folks trying the usb but complaining the levels are too low.
Ours are plenty high thanks to the i/f so we have to lower the Qu levels we send.
Make sure you have the right driver. Be sure you are sending to the output going to the presonus.
Inputs should be as I recall on 1 & 2. Assuming you send stereo to presonus not just one channel.
No output comes from it?? You trying to send back to the Qu ?? why ?
If you mean no input coming in then check the driver and the other bizarro settings that need fixing in win 10.