Hi Kpjax,
The ME system is fed signal by dSnake outputs 21-60. On the Qu, these are found in the Setup > IO Patch > Monitor tab. These signals are then passed to each ME unit connected to the dSnake port.
The ME-500 automatically takes the first 16 channels in this monitor tab and assigns them to the 16 keys. In comparison to the ME-1, which can configure the key assignments on the unit, the ME-500 would require an assignment change on the desk.
Thanks!
Alex