Thank you Mark, I did check it and yes I have the ASIOTM/WDM driver installed, also the latest firmware of the SQ5.
I will probably work when using prologic or cakewalk but what I want to do is use 3 different programs:
Spotify with the equalify plugin: Set to “SQ Speaker 1”
Karafun: Set to “SQ Speaker 2”
KaraokeMedia: Set to “SQ Speaker 3”
PC Sound (Youtube): Set to “SQ Speaker 4”
On the mixer I can set the USB-B to different channels but in my PC I only have one option, that is “SQ Speaker”