@JParker
Really need more details of what you are doing and how you are doing it in order to make an informed opinion of what needs to be done.
We run ours direct via the line inputs.
If you are using USBb then you need to make internal settings per the manual to set the line inputs.
Fn and then select source and set channels you want from the usbb vs other sources dsnake or local.
There are other tweaks you can make on that usbb input too. The manual is fairly good on this.
Sometimes you also need to make settings in the PC to ensure the data is going to the USBb for the Qu to see it.