@Mike C
Not really – the different options for USB out are achieved with analogue/hardware switches, which affect USB outputs 3&4 on the ZEDi-10 and ZEDi-10FX.
On Windows, with the driver installed, there are two stereo devices (+ 4x mono) presented for use with any app, and via ASIO and a DAW you can generally route as you like.
On Mac some apps will see the first two channels as stereo and then the rest summed to mono.
There are work-arounds using software like Jack audio to repatch in this case, but it’s not really cleaner as it takes quite a bit of setting up.
If you want to explore this further, please contact us through support.allen-heath.com
Cheers,
Keith.