Keith
most of the DAW’s use one given sample rate for a project
and changing this, will mostly lead to the wrong playback speed
it is different for new projects with different sample rate than imported files
here will most DAW’s at least these few I know convert the files to the project sample rate
Nuendo acts like Cubase in that case, they are the same on the audio engine basics
but the problem with older projects persists
that’s why I never suggest a low budget digital mixer as main audio device for commercial studios
in project studios this is a no brainer