Are the any drawbacks or anything that is integrated in the CL series that wont allow the full use of a Dante enabled hub and ME-1’s?
Not to the best of my knowledge. Check the CL is set to operate at 48kHz. You want the CL to be the preferred master clock on the Dante network in Dante Controller.
Do the Outputs of the ME-U hub operate on the D-snake Language?
Generally speaking yes, although depending on the incoming stream, they can also distribute an Aviom feed.
can one of the outs of the ME-U(normally used for ME-1 units) feed into the D-snake input of a QU mixer?
No I’m afraid. Qu mixers cannot sync from external sources.
Hope this helps.