Reply To: USB Streaming (USB B)

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Even if Garage Band is aware of multichannel audio interfaces on Input, it seems to be locked down to always send to first two channels of any output device (clear answer here).
If you want to spend USD 75 Loopback may help. You could easily configure a virtual device and at least duplicate the first two channels to any other channel sent to the Qu.
Similar should be possible with the free JACK application, but I couldn’t get that to work with my OSX 10.10 (Yosemite).