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I believe some desks can send/return to and from the computer on the same mixer channels. I have never used a mixer like that, I don’t even know what the functionality is called, so someone correct me if I’m wrong. But I believe I have seen it mentioned as a feature of other mixers.
I’m guessing that would mean you could use a VST effect as an insert on a channel? Currently, on my Qu-16, I can send a track to a channel in the computer, add a VST and return route it to another channel on the mixer. I lose a channel that way. I don’t know what other benefits the “inline” feature would bring, but I thought I’d mention it here. The lack of that functionality may be the reason the Qu series aren’t always thought of as recording mixers.
Sorry for the lack of technical specificity.