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I’ve been wondering about the latency as well. I wanted to use the PCIe card for I/O between two Macs (A 2008 8-Core and a 2012 6-Core) with the 8-Core being used for Virtual Instruments and the 6-Core for mixing/effects as well.

CMattE, have you tried the Dante card in this fashion ? If it is stable and can handle a decent amount of I/O, I’m all in!