On most of my installs, because of the unfamiliarity of the console for the client, my set up is usualy this:
Layer A:
Inputs 1-20 , DCA 1-8
Layer B:
Inputs 21-40, Sends 1-8
Layer C:
Inputs 41-64 (some stereo), Matrixes and Mains
Layer 
Fx returns, FX sends
Then, ill let them change it up to taste.
Gil Parente
Design & Integration
Entertainment Arts, Inc.
iLive 176, T112
iDR48 , iDR16, iDR10
Multiple iPads
Dante
Etc..
