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I think yes, the architecture supports multiple changes on different busses at the same time. We run at least 3 editor sessions at the same time, one is the keyboarder tweaking his own IEMs, the next one is the FOH, and the last one doing monitor mix.
We had never an issue, when different buses where mixed at the same time.
I think, that you are right the musicians don’t want to get in touch with technics, especially when it’s PC based. For this the interface must be as simple as possible ;), and there should be zero space to make a mistake…

Editor only (3 times)
Korg nano