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Hi Stuart,
we are using a RME HDSPe MADIFACE. It has a ExprexxCrad/34 connector for Notebooks. There is also a HDSP MADI card for desktop computers with a PCI express interface. I’m not shure if there is a USB solution because MADI has a high data rate and needs a stable and accurate clock signal. More about RME: http://www.rme-audio.com

Protools as IMHO no MADI interface. But there are 3rd party solutions – MADI to protools converter (Solid State Logic) for example.